| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Lutein | 📋 | ✍ | ⛔ | | 38363462 | Lutein and Zeaxanthin Supplementation Improves Dynamic Visual and Cognitive Performance in Children: A Randomized, Double-Blind, Parallel, Placebo-Controlled Study |
| Curcumin | 📋 | ✍ | ⛔ | | 38345446 | The effect of curcumin on on intravitreal proinflammatory cytokines, oxidative stress markers, and vascular endothelial growth factor in an experimental model of diabetic retinopathy |
| Goji Berry | 📋 | ✍ | ⛔ | | 38202631 | Exploring the Role of Lycium barbarum Polysaccharide in Corneal Injury Repair and Investigating the Relevant Mechanisms through In Vivo and In Vitro Experiments |
| Resveratrol | 📋 | ✍ | ⛔ | | 38678810 | Resveratrol has neuroprotective effects and plays an anti-inflammatory role through Dectin-1/p38 pathway in Aspergillus fumigatus keratitis |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38469994 | Serum vitamin D is substantially reduced and predicts flares in diabetic retinopathy patients |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 38363462 | Lutein and Zeaxanthin Supplementation Improves Dynamic Visual and Cognitive Performance in Children: A Randomized, Double-Blind, Parallel, Placebo-Controlled Study |
| Melatonin | 📋 | ✍ | ⛔ | | 38008231 | Melatonin protects photoreceptor cells against ferroptosis in dry AMD disorder by inhibiting GSK-3B/Fyn-dependent Nrf2 nuclear translocation |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 38625392 | Correlation between omega-3 intake and the incidence of diabetic retinopathy based on NHANES from 2005 to 2008 |
| Astaxanthin | 📋 | ✍ | ⛔ | | 38667772 | Marine Natural Products Rescuing the Eye: A Narrative Review |
| Citicoline | 📋 | ✍ | ⛔ | | 37768938 | Efficacy of citicoline as a supplement in glaucoma patients: A systematic review |
| Quercetin | 📋 | ✍ | ⛔ | | 38673877 | Quercetin Impairs the Growth of Uveal Melanoma Cells by Interfering with Glucose Uptake and Metabolism |
| Bilberry | 📋 | ✍ | ⛔ | | 38612968 | Extract from Aronia melanocarpa, Lonicera caerulea, and Vaccinium myrtillus Improves near Visual Acuity in People with Presbyopia |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 36882511 | Ginkgo biloba extracts improve choroidal circulation leading to suppression of myopia in mice |
| TUDCA | 📋 | ✍ | ⛔ | | 36791327 | Tauroursodeoxycholic Acid Alleviates Endoplasmic Reticulum Stress-Mediated Visual Deficits in Diabetic tie2-TNF Transgenic Mice via TGR5 Signaling |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 38684884 | Nutritional interventions to prevent retinopathy of prematurity |
| Micronutrients | 📋 | | ⛔ | | 38337657 | Impact of Dietary Nutrients on the Prevalence of Dry Eye Syndrome among Korean Women Aged 40 and above: Evidence from the Korea National Health and Nutrition Examination Survey |
| EGCG | 📋 | ✍ | ⛔ | | 37979829 | Epigallocatechin gallate delays age-related cataract development via the RASSF2/AKT pathway |
| Vitamin C | 📋 | ✍ | ⛔ | | 38727927 | Vitamin C alleviates hyperglycemic stress in retinal pigment epithelial cells |
| Metformin | 📋 | ✍ | ⛔ | | 38408173 | Association of metformin use with risk of newly onset neovascular age-related macular degeneration development |
| Vitamin A | 📋 | ✍ | ⛔ | | 38177180 | The relationship between blood vitamin A levels and diabetic retinopathy: a population-based study |
| Ginsenosides | 📋 | ✍ | ⛔ | | 37819496 | GRg1 inhibits the TLR4/NF-kB signaling pathway by upregulating miR-216a-5p to reduce growth factors and inflammatory cytokines in DR |
| Berberine | 📋 | ✍ | ⛔ | | 38702033 | Berberine alleviates diabetic retinopathy by regulating the Th17/Treg ratio |
| Saffron | 📋 | ✍ | ⛔ | | 38485112 | Saffron therapy for the ongoing treatment of age-related macular degeneration |
| Vitamin E | 📋 | ✍ | ⛔ | | 36090588 | The Amelioration of Detrimental Biochemical Anomalies by Supplementing B, C, and E Vitamins in Subjects with Type 2 Diabetes Mellitus May Reduce the Rate of Development of Diabetic Retinopathy |
| Puerarin | 📋 | ✍ | ⛔ | | 38196088 | Puerarin Attenuates Iron Overload-Induced Ferroptosis in Retina through a Nrf2-Mediated Mechanism |
| Anthocyanins | 📋 | ✍ | ⛔ | | 34376917 | Effects of anthocyanin, astaxanthin, and lutein on eye functions: a randomized, double-blind, placebo-controlled study |
| CoQ10 | 📋 | ✍ | ⛔ | | 36982157 | The Role of Citicoline and Coenzyme Q10 in Retinal Pathology |
| Zinc | 📋 | ✍ | ⛔ | | 36899910 | Zinc Supplementation Induced Transcriptional Changes in Primary Human Retinal Pigment Epithelium: A Single-Cell RNA Sequencing Study to Understand Age-Related Macular Degeneration |
| Blueberry | 📋 | ✍ | ⛔ | | 38432561 | Intake of blueberries, anthocyanins, and risk of eye disease in women |
| Carotenoids | 📋 | ✍ | ⛔ | | 37447314 | Association of Plasma Vitamins and Carotenoids, DNA Methylation of LCAT, and Risk of Age-Related Macular Degeneration |
| Crocetin | 📋 | | | | 38097101 | Crocetin inhibits choroidal neovascularization in both in vitro and in vivo models |
| Hyaluronic Acid | 📋 | ✍ | ⛔ | | 37986246 | Acupuncture for aqueous deficiency dry eye: a randomized controlled trial |
| Sulforaphane | 📋 | ✍ | ⛔ | | 38521828 | Balanced activation of Nrf-2/ARE mediates the protective effect of sulforaphane on keratoconus in the cell mechanical microenvironment |
| Antioxidants | 📋 | | ⛔ | | 38582248 | Effect of Antioxidant Supplementation on Macular Pigment Optical Density and Visual Functions: A systematic review and network meta-analysis of randomized controlled trials |
| Astragalosides | 📋 | ✍ | ⛔ | | 38286267 | Discovery of Astragaloside IV against high glucose-induced apoptosis in retinal ganglion cells: bioinformatics and in vitro studies |
| Luteolin | 📋 | ✍ | ⛔ | | 38633216 | SIRT1/P53 in retinal pigment epithelial cells in diabetic retinopathy: a gene co-expression analysis and He-Ying-Qing-Re formula treatment |
| Crocin | 📋 | ✍ | ⛔ | | 35565684 | The Functional Vision Restorative Effect of Crocin via the BDNF-TrkB Pathway: An In Vivo Study |
| Food | 📋 | | | | 37561825 | Retinopathy of Prematurity: The Role of Nutrition |
| Magnesium | 📋 | ✍ | ⛔ | | 37851631 | Association between dietary calcium, potassium, and magnesium consumption and glaucoma |
| Ginseng | 📋 | ✍ | ⛔ | | 37689326 | Panax notoginseng saponins alleviate diabetic retinopathy by inhibiting retinal inflammation: Association with the NF-κB signaling pathway |
| Hesperidin | 📋 | ✍ | ⛔ | | 36861869 | Pseudomonas aeruginosa Keratitis in Rats: Study of the Effect of Topical 5% Hesperidin Practice on Healing |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 35128081 | Thiol antioxidants protect human lens epithelial (HLE B-3) cells against tert-butyl hydroperoxide-induced oxidative damage and cytotoxicity |
| Naringenin | 📋 | ✍ | ⛔ | | 38052414 | Protective effect of the natural flavonoid naringenin in mouse models of retinal injury |
| Nicotinamide | 📋 | ✍ | ⛔ | | 38496666 | Morphology, but not microtubules, of the retinal nerve fibers are protected by nicotinamide in glaucoma mice |
| NMN | 📋 | ✍ | ⛔ | | 37880000 | Glaucoma: neuroprotection with NAD-based therapeutic interventions |
| Salidroside | 📋 | | | | 38243268 | Salidroside protects RGC from pyroptosis in diabetes-induced retinopathy associated with NLRP3, NFEZL2 and NGKB1, revealed by network pharmacology analysis and experimental validation |
| Chrysin | 📋 | ✍ | ⛔ | | 38222446 | Investigation of the antioxidant effect of Chrysin in an experimental cataract model created in chick embryos |
| Fisetin | 📋 | ✍ | ⛔ | | 36777991 | Fisetin Prevents Angiogenesis in Diabetic Retinopathy by Downregulating VEGF |
| Medicinal Plants | 📋 | | | | 38027044 | Herbal and Natural Treatments for the Management of the Glaucoma: An Update |
| Persimmon | 📋 | | ⛔ | | 35056129 | Persimmon Leaves ( Diospyros kaki) Extract Enhances the Viability of Human Corneal Endothelial Cells by Improving Na +-K +-ATPase Activity |
| Pine Bark | 📋 | ✍ | ⛔ | | 35637465 | Pycnogenol a promising remedy for diabetic keratopathy in experimentally induced corneal alkali burns in diabetic rats |
| Trehalose | 📋 | | ⛔ | | 38068353 | Trehalose and Dry Eye Disease: A Comprehensive Systematic Review of Randomized Controlled Trials |
| Apigenin | 📋 | ✍ | ⛔ | | 38718570 | Apigenin suppresses epithelial-mesenchymal transition in high glucose-induced retinal pigment epithelial cell by inhibiting CBP/p300-mediated histone acetylation |
| Baicalein | 📋 | ✍ | ⛔ | | 37979815 | Baicalein improves Na2SeO3 induced cataract by enhancing the antioxidant capacity of juvenile Sprague Dawley Rat |
| Flavonoids | 📋 | | ⛔ | | 36652737 | Role of flavonoids in age-related macular degeneration |
| Cannabidiol | 📋 | ✍ | ⛔ | | 33917605 | Cannabidiol and the Canonical WNT/β-Catenin Pathway in Glaucoma |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 37999206 | Lutein-Rich Beverage Alleviates Visual Fatigue in the Hyperglycemia Model of Sprague-Dawley Rats |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 37138572 | Association of n-3 polyunsaturated fatty acid intakes with juvenile myopia: A cross-sectional study based on the NHANES database |
| Genistein | 📋 | ✍ | ⛔ | | 38272381 | Genistein stimulates the viability and prevents myofibroblastic transformation in human trabecular meshwork cells stimulated by TGF-β |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 38397833 | Amelioration of Functional, Metabolic, and Morphological Deterioration in the Retina following Retinal Detachment by Green Tea Extract |
| Hesperetin | 📋 | | | | 38540165 | Computational and Experimental Approaches Exploring the Role of Hesperetin in Improving Autophagy in Rat Diabetic Retinopathy |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 37880000 | Glaucoma: neuroprotection with NAD-based therapeutic interventions |
| PUFA | 📋 | | | | 38612907 | Understanding the Impact of Polyunsaturated Fatty Acids on Age-Related Macular Degeneration: A Review |
| Rapamycin | 📋 | ✍ | | | 37060809 | Rapamycin suppresses neuroinflammation and protects retinal ganglion cell loss after optic nerve crush |
| Trans-Resveratrol | 📋 | | | | 37261387 | Low-Dose Trans-Resveratrol Ameliorates Diabetes-Induced Retinal Ganglion Cell Degeneration via TyrRS/c-Jun Pathway |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 34091874 | Citicoline and Vitamin B 12 Eye Drops in Type 1 Diabetes: Results of a 36-Month Pilot Study Evaluating Macular Electrophysiological Changes |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 33114699 | A Mechanistic Review of β-Carotene, Lutein, and Zeaxanthin in Eye Health and Disease |
| Blackcurrant | 📋 | ✍ | ⛔ | | 35624696 | Protective Effect of Ribes nigrum Extract against Blue Light-Induced Retinal Degeneration In Vitro and In Vivo |
| Cordyceps | 📋 | ✍ | ⛔ | | 37513520 | Preventative Effects of Cordyceps cicadae Mycelial Extracts on the Early-Stage Development of Cataracts in UVB-Induced Mice Cataract Model |
| Lycopene | 📋 | ✍ | ⛔ | | 37070131 | Lycopene inhibits endothelial-to-mesenchymal transition of choroidal vascular endothelial cells in laser-induced mouse choroidal neovascularization |
| NAD | 📋 | | | | 35768245 | The Role of NAD + and Nicotinamide (Vitamin B3) in Glaucoma: A Literature Review |
| Taurine | 📋 | ✍ | ⛔ | | 37111062 | Taurine: A Source and Application for the Relief of Visual Fatigue |
| Tea Tree Essential Oil | 📋 | | ⛔ | | 37252177 | Dry eye disease: A review of anti-inflammatory therapies |
| UDCA | 📋 | ✍ | ⛔ | | 35337132 | Comparative Analysis of Urso- and Tauroursodeoxycholic Acid Neuroprotective Effects on Retinal Degeneration Models |
| Vitamin B Complex | 📋 | | ⛔ | | 38609427 | Association of dietary intake of B vitamins with glaucoma |
| Bee Propolis | 📋 | ✍ | ⛔ | | 36422549 | Therapeutic Potential of Honey and Propolis on Ocular Disease |
| Dihydroquercetin | 📋 | | | | 33121287 | Effect of taxifolin on cisplatin-associated oxidative optic nerve damage in rats |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 36119027 | Ferulic acid alleviates retinal neovascularization by modulating microglia/macrophage polarization through the ROS/NF-κB axis |
| Fucoidan | 📋 | ✍ | ⛔ | | 38360728 | Fucoidan modulates SIRT1 and NLRP3 to alleviate hypertensive retinopathy: in vivo and in vitro insights |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 38667772 | Marine Natural Products Rescuing the Eye: A Narrative Review |
| Genipin | 📋 | | | | 38626646 | Genipin ameliorates diabetic retinopathy via the HIF-1α and AGEs-RAGE pathways |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 36703096 | Anthocyanin oligomer (grape skin extract) administration improves dry eye disease: A randomised, double-blind, placebo-controlled study |
| Kaempferol | 📋 | ✍ | ⛔ | | 38626549 | Immunomodulatory effects of Kaempferol on microglial and Macrophage cells during the progression of diabetic retinopathy |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 33356611 | Chronopharmacology of the alpha-lipoic acid/nifedipine/glimepiride combination in the amelioration of retinopathy in rats |
| Nobiletin | 📋 | ✍ | | | 36775448 | Nobiletin protects retinal ganglion cells in models of ocular hypertension in vivo and hypoxia in vitro |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 37926095 | Association between dietary consumption of vitamin B1 and advanced age-related macular degeneration: a cross-sectional observational study in NHANES 2005-2008 |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 37731716 | Restored retinal physiology after administration of niacin with citicoline in a mouse model of hypertensive glaucoma |
| Vitamins | 📋 | | | | 37489231 | Association Between Vitamin Deficiencies and Ophthalmological Conditions |
| Astragalus Root | 📋 | ✍ | ⛔ | | 35088163 | Hypobaric hypoxia triggers pyroptosis in the retina via NLRP3 inflammasome activation |
| Caffeine | 📋 | ✍ | ⛔ | | 36904168 | Caffeine and the Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus: Findings from Clinical and Experimental Studies |
| Fish Oil | 📋 | ✍ | ⛔ | | 37029593 | Fish oil in glaucoma treatment: From biological functions to clinical potential |
| Forskolin | 📋 | ✍ | ⛔ | | 34188435 | Forskolin eye drops improve retinal damage from ischemia/reperfusion |
| Grape | 📋 | | ⛔ | | 38561079 | A grape-supplemented diet prevented ultraviolet (UV) radiation-induced cataract by regulating Nrf2 and XIAP pathways |
| Pterostilbene | 📋 | ✍ | ⛔ | | 35556682 | The Role of Polyphenols on Blue Light-Induced Retinal Pigment Cell Damage |
| Red Sage | 📋 | ✍ | ⛔ | | 37741257 | Fructus Lycii and Salvia miltiorrhiza Bunge extract attenuate oxidative stress-induced photoreceptor ferroptosis in retinitis pigmentosa |
| Selenium | 📋 | ✍ | ⛔ | | 36776608 | Selenium intake help prevent age-related cataract formation: Evidence from NHANES 2001-2008 |
| Thymoquinone | 📋 | | ⛔ | | 37797357 | Thymoquinone attenuates inflammation in C. Albicans keratitis by activating Nrf2/HO-1 signaling pathway and reducing fungal load |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 33264161 | Cool Crosslinking: Riboflavin at 4°C for Pain Management After Crosslinking for Keratoconus Patients, A Randomized Clinical Trial |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 38194486 | Association of vitamin B6 intake with the risk and prognosis of diabetic retinopathy: a NHANES-based study |
| Baicalin | 📋 | ✍ | ⛔ | | 36442621 | Baicalin prevents fibrosis of human trabecular meshwork cells via inhibiting the MyD88/NF-κB pathway |
| Chondroitin | 📋 | ✍ | ⛔ | | 37443739 | Role of Chondroitin Sulfate Proteoglycan 5 in Steroid-Induced Cataract |
| Diosmin | 📋 | ✍ | ⛔ | | 29258224 | The Benefits of the Citrus Flavonoid Diosmin on Human Retinal Pigment Epithelial Cells under High-Glucose Conditions |
| Egg | 📋 | | ⛔ | | 33491232 | A positive effect of egg consumption on macular pigment and healthy vision: a systematic review and meta-analysis of clinical trials |
| Fenugreek | 📋 | ✍ | ⛔ | | 19823776 | Trigonella Foenum-Graecum (Fenugreek) Protects Against Selenite-Induced Oxidative Stress in Experimental Cataractogenesis |
| Fish | 📋 | | ⛔ | | 35217394 | Potential mechanisms of macular degeneration protection by fatty fish consumption |
| Folate | 📋 | ✍ | ⛔ | | 38170538 | Association Between High Blood Folate Levels and Glaucoma in a Representative Korean Population |
| Glabridin | 📋 | | | | 38346287 | The Therapeutic Role and Mechanism of Glabridin Under Aspergillus fumigatus Infection |
| Iodine | 📋 | ✍ | ⛔ | | 37699559 | Successful Management of Fungal Keratitis Caused by Multidrug-Resistant Cladosporium Species Using Povidone-Iodine: A Case Report |
| Knotweed | 📋 | ✍ | ⛔ | | 36242032 | Fallopia Japonica and Prunella vulgaris inhibit myopia progression by suppressing AKT and NFκB mediated inflammatory reactions |
| Onion | 📋 | ✍ | ⛔ | | 38309514 | Investigating the therapeutic potential of Allium cepa extract in combating pesticide exposure induced ocular damage |
| Paeoniflorin | 📋 | | | | 35653799 | Paeoniflorin alleviates the progression of retinal vein occlusion via inhibiting hypoxia inducible factor-1α/vascular endothelial growth factor/STAT3 pathway |
| Phytochemicals | 📋 | | | | 38725662 | The mechanisms of natural products for eye disorders by targeting mitochondrial dysfunction |
| Polyphenols | 📋 | | | | 37979379 | The potential benefits of polyphenols for corneal diseases |
| Progesterone | 📋 | ✍ | ⛔ | | 37344856 | Progesterone attenuates Th17-cell pathogenicity in autoimmune uveitis via Id2/Pim1 axis |
| Rutin | 📋 | ✍ | ⛔ | | 38325842 | Rutin promotes M2 phenotype microglia polarization by suppressing the JAK/STAT3 signaling to protect against retinal ischemia-reperfusion injury |
| Scutellarin | 📋 | | | | 38014534 | Scutellarin Alleviates Diabetic Retinopathy via the Suppression of Nucleotide-Binding Oligomerization Domain (NOD)-Like Receptor Pyrin Domain Containing Protein 3 Inflammasome Activation |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 30497904 | Effects of a sea buckthorn oil spray emulsion on dry eye |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 34874218 | The palliative effects of folic acid on retinal microvessels in diabetic retinopathy via regulating the metabolism of DNA methylation and hydroxymethylation |
| Andrographis | 📋 | ✍ | ⛔ | | 38638635 | Andrographis Paniculata (Burm. F.) Flavonoid Compound and Prevention of Diabetic Retinopathy |
| Andrographolide | 📋 | | | | 36291655 | Andrographolide Inhibits Corneal Fibroblast to Myofibroblast Differentiation In Vitro |
| Arachidonic Acid | 📋 | ✍ | ⛔ | | 38684884 | Nutritional interventions to prevent retinopathy of prematurity |
| Bromelain | 📋 | ✍ | ⛔ | | 38068370 | Anatomical and Functional Effects of an Oral Supplementation of Bromelain and Curcugreen in Patients with Focal Diabetic Macular Edema |
| Calcium | 📋 | ✍ | ⛔ | | 37851631 | Association between dietary calcium, potassium, and magnesium consumption and glaucoma |
| Carnosic Acid | 📋 | | | | 32277323 | Protective effects of carnosic acid on retinal ganglion cells in acute ocular hypertension rats |
| Castor Oil | 📋 | ✍ | ⛔ | | 33037703 | Therapeutic potential of castor oil in managing blepharitis, meibomian gland dysfunction and dry eye |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 38189160 | Antioxidant potential of chlorogenic acid in Age-Related eye diseases |
| Coconut Oil | 📋 | | ⛔ | | 33130579 | Reversal of diabetic tractional retinal detachment attributed to keto diet |
| Coffee | 📋 | ✍ | ⛔ | | 35241707 | Coffee consumption and diabetic retinopathy in adults with diabetes mellitus |
| Cornus | 📋 | | | | 37138788 | Morroniside Ameliorates Endotoxin-Induced Uveitis by Regulating the M1/M2 Polarization Balance of Macrophages |
| Diosmetin | 📋 | | | | 35481411 | Diosmetin attenuates oxidative stress-induced damage to lens epithelial cells via the mitogen-activated protein kinase (MAPK) pathway |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 28740299 | Attenuation of diabetic retinopathy in rats by ellagic acid through inhibition of AGE formation |
| Essential Fatty Acids | 📋 | ✍ | | | 33692241 | Fatty Acids and Lipid Derivatives Protecting Photooxidative Attack in Age-related Macular Degeneration |
| Garlic | 📋 | ✍ | ⛔ | | 35875346 | Evaluation of the Effect of Garlic Tablet as a Complementary Treatment for Patients with Diabetic Retinopathy |
| Ginger extract | 📋 | ✍ | ⛔ | | 38123793 | A ginger extract improves ocular blood flow in rats with endothelin-induced retinal blood flow dysfunction |
| Honey | 📋 | ✍ | ⛔ | | 37242545 | Honey-Related Treatment Strategies in Dry Eye Disease |
| L-Carnitine | 📋 | ✍ | ⛔ | | 37511574 | L-Carnitine Suppresses Transient Receptor Potential Vanilloid Type 1 Activation in Human Corneal Epithelial Cells |
| L-Carnosine | 📋 | ✍ | ⛔ | | 37110558 | Carnosine Counteracts the Molecular Alterations Aβ Oligomers-Induced in Human Retinal Pigment Epithelial Cells |
| L-Citrulline | 📋 | ✍ | ⛔ | | 35460170 | Citrulline protects human retinal pigment epithelium from hydrogen peroxide and iron/ascorbate induced damages |
| Licorice Root | 📋 | ✍ | ⛔ | | 32122840 | Anti-angiogenic effect of EGHB010, a standardized herbal formula of Paeoniae radix and Glycyrrhizae radix |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 31144032 | Efficient therapeutic effect of Nigella sativa aqueous extract and chitosan nanoparticles against experimentally induced Acanthamoeba keratitis |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 31922452 | Neuroprotective effects of oleuropein on retina photoreceptors cells primary culture and olive leaf extract and oleuropein inhibitory effects on aldose reductase in a diabetic model: Meriones shawi |
| Peony | 📋 | | ⛔ | | 34234414 | Exploration of the Effect and Mechanism of Fructus Lycii, Rehmanniae Radix Praeparata, and Paeonia lactiflora in the Treatment of AMD Based on Network Pharmacology and in vitro Experimental Verification |
| Punicalagin | 📋 | ✍ | ⛔ | | 34797193 | Antifungal and anti-inflammatory effect of punicalagin on murine Aspergillus fumigatus keratitis |
| Spearmint | 📋 | | ⛔ | | 37917085 | Efficacy of a Spearmint (Mentha spicata L.) Extract as Nutritional Support in a Rat Model of Hypertensive Glaucoma |
| Spirulina | 📋 | ✍ | ⛔ | | 38667772 | Marine Natural Products Rescuing the Eye: A Narrative Review |
| Sweet Potato | 📋 | | ⛔ | | 37274105 | The role of lutein-rich purple sweet potato leaf extract on the amelioration of diabetic retinopathy in streptozotocin-induced Sprague-Dawley rats |
| Tanshinone | 📋 | | | | 36437835 | Study on the Antioxidant Effect of Tanshinone IIA on Diabetic Retinopathy and Its Mechanism Based on Integrated Pharmacology |
| Thymol | 📋 | ✍ | ⛔ | | 36517045 | Thymol Ameliorates Aspergillus fumigatus Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1β Signal Expression and Reducing Necroptosis and Pyroptosis |
| Turmeric | 📋 | ✍ | ⛔ | | 35956066 | Anatomical and Functional Effects of Oral Administration of Curcuma Longa and Boswellia Serrata Combination in Patients with Treatment-Naïve Diabetic Macular Edema |
| Wormwood | 📋 | ✍ | ⛔ | | 37159329 | Artesunate protects against ocular fibrosis by suppressing fibroblast activation and inducing mitochondria-dependent ferroptosis |
| Aloe Vera | 📋 | ✍ | ⛔ | | 33672553 | Health Potential of Aloe vera against Oxidative Stress Induced Corneal Damage: An "In Vitro" Study |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 35057481 | Dietary Alpha-Linolenic Acid Supports High Retinal DHA Levels |
| Arctigenin | 📋 | | | | 36858576 | Arctigenin Prevents Retinal Edema in a Murine Retinal Vein Occlusion Model |
| Arctiin | 📋 | | | | 32297701 | Arctiin attenuates high glucose-induced human retinal capillary endothelial cell proliferation by regulating ROCK1/PTEN/PI3K/Akt/VEGF pathway in vitro |
| Arnica | 📋 | ✍ | ⛔ | | 36220097 | Neuroprotective Properties of Chlorogenic Acid and 4,5-Caffeoylquinic Acid from Brazilian arnica (Lychnophora ericoides) after Acute Retinal Ischemia |
| Asiatic Acid | 📋 | | | | 36769706 | Differential Modulation of the Excitatory and Inhibitory Synaptic Circuits of Retinal Ganglion Cells via Asiatic Acid in a Chronic Glaucoma Rat Model |
| Asiaticoside | 📋 | | | | 35038080 | The modulation of cAMP/PKA pathway by asiaticoside ameliorates high glucose-induced inflammation and apoptosis of retinal pigment epithelial cells |
| Astragalin | 📋 | | | | 37602342 | Astragalin attenuates diabetic cataracts via inhibiting aldose reductase activity in rats |
| Barberry | 📋 | ✍ | ⛔ | | 35697191 | Berberis dictyophylla F. inhibits angiogenesis and apoptosis of diabetic retinopathy via suppressing HIF-1α/VEGF/DLL-4/Notch-1 pathway |
| Bay Leaf | 📋 | | ⛔ | | 27982689 | The effect of Laurus nobilis on the blood and lenses antioxidant activity in rabbit under fat-enriched diet |
| BCAA | 📋 | ✍ | ⛔ | | 37432261 | Branched-Chain Amino Acids Metabolism and Their Roles in Retinopathy: From Relevance to Mechanism |
| Betaine | 📋 | ✍ | ⛔ | | 35777472 | Preclinical study of a new matrix to help the ocular surface in dry eye disease |
| Biochanin A | 📋 | | | | 38679123 | Biochanin A: Disrupting the Inflammatory Vicious Cycle for Dry Eye Disease |
| Black Tea | 📋 | ✍ | ⛔ | | 38601618 | Potential therapeutic effects of green tea (Camellia sinensis) in eye diseases, a review |
| Burdock | 📋 | | ⛔ | | 32283798 | Suppressive Effect of Arctium Lappa L. Leaves on Retinal Damage Against A2E-Induced ARPE-19 Cells and Mice |
| CAPE | 📋 | | | | 25860848 | The Effects of Nigella Sativa Oil, Thymoquinone, Propolis, and Caffeic Acid Phenethyl Ester on Radiation-Induced Cataract |
| Carnosol | 📋 | | | | 36300534 | Carnosol attenuates high glucose damage in human retinal endothelial cells through regulation of ERK/Nrf2/HO-1 pathway |
| Catechins | 📋 | | | | 37507860 | Green Tea Catechins as Therapeutic Antioxidants for Glaucoma Treatment |
| Chokeberry | 📋 | ✍ | ⛔ | | 38612968 | Extract from Aronia melanocarpa, Lonicera caerulea, and Vaccinium myrtillus Improves near Visual Acuity in People with Presbyopia |
| Choline | 📋 | ✍ | ⛔ | | 33946979 | Role of Choline in Ocular Diseases |
| Cocoa | 📋 | ✍ | ⛔ | | 14709774 | Ingestion of proanthocyanidins derived from cacao inhibits diabetes-induced cataract formation in rats |
| Copper | 📋 | ✍ | ⛔ | | 18848316 | Reduced Zinc and Copper in the Retinal Pigment Epithelium and Choroid in Age-Related Macular Degeneration |
| Coriander | 📋 | | ⛔ | | 28904737 | Anticataractogenesis and Antiretinopathy Effects of the Novel Protective Agent Containing the Combined Extract of Mango and Vietnamese Coriander in STZ-Diabetic Rats |
| Cyanidin | 📋 | ✍ | | | 32640796 | Cyanidin-3-O-glucoside Protects Lens Epithelial Cells Against High Glucose Induced Apoptosis and Prevents Cataract Formation via Suppressing NF-κB Activation and Cox-2 Expression |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 33536772 | Dihydromyricetin Alleviates High Glucose-Induced Oxidative Stress and Apoptosis in Human Retinal Pigment Epithelial Cells by Downregulating miR-34a Expression |
| Diosgenin | 📋 | | | | 36881067 | Diosgenin, a Natural Steroidal Sapogenin, Alleviates the Progression of Diabetic Retinopathy in Diabetic Mice |
| EDTA | 📋 | ✍ | ⛔ | | 24509160 | Metal chelator combined with permeability enhancer ameliorates oxidative stress-associated neurodegeneration in rat eyes with elevated intraocular pressure |
| Emodin | 📋 | | ⛔ | | 33167932 | Emodin protected against retinal ischemia insulted neurons through the downregulation of protein overexpression of β-catenin and vascular endothelium factor |
| Eugenol | 📋 | | | | 38249123 | Eugenol ameliorates uveitis in mice with experimental autoimmune encephalomyelitis through the suppression of key inflammatory genes |
| Formononetin | 📋 | | | | 38593508 | Formononetin protects against Aspergillus fumigatus Keratitis: Targeting inflammation and fungal load |
| Galangin | 📋 | | | | 30597356 | Natural flavonoid galangin alleviates microglia-trigged blood-retinal barrier dysfunction during the development of diabetic retinopathy |
| Gallic Acid | 📋 | | ⛔ | | 37122017 | Anti-inflammatory and antioxidative effects of gallic acid on experimental dry eye: in vitro and in vivo studies |
| Gardenia | 📋 | | ⛔ | | 36902379 | Gardenia jasminoides Extract, with a Melatonin-like Activity, Protects against Digital Stress and Reverses Signs of Aging |
| Geniposide | 📋 | | | | 34938383 | Geniposide Attenuates Hyperglycemia-Induced Oxidative Stress and Inflammation by Activating the Nrf2 Signaling Pathway in Experimental Diabetic Retinopathy |
| Ginkgolides | 📋 | | | | 38442447 | The anti-apoptotic role of Ginkgolide B via mitochondrial permeability transition pore inhibition in retinal ischemia-reperfusion |
| Glucosamine | 📋 | ✍ | ⛔ | | 34506973 | Glucosamine protects against neuronal but not vascular damage in experimental diabetic retinopathy |
| Glutathione | 📋 | ✍ | ⛔ | | 38673745 | The Role of Glutathione in Age-Related Macular Degeneration (AMD) |
| Gotu Kola | 📋 | ✍ | ⛔ | | 33923585 | Preventive Effects against Retinal Degeneration by Centella asiatica Extract (CA-HE50) and Asiaticoside through Apoptosis Suppression by the Nrf2/HO-1 Signaling Pathway |
| Hyperoside | 📋 | | | | 37819682 | Hyperoside alleviates photoreceptor degeneration by preventing cell senescence through AMPK-ULK1 signaling |
| Indian Gooseberry | 📋 | | ⛔ | | 35168075 | Triphala churna ameliorates retinopathy in diabetic rats |
| Kacip Fatimah | 📋 | ✍ | ⛔ | | 34622461 | Gallic acid and myricetin-rich Labisia pumila extract mitigated multiple diabetic eye disorders in rats |
| Kudzu Root | 📋 | ✍ | ⛔ | | 31534464 | Pueraria lobata Extract Protects Hydrogen Peroxide-Induced Human Retinal Pigment Epithelial Cells Death and Membrane Permeability |
| L-Arginine | 📋 | ✍ | ⛔ | | 35399942 | A Hypothesis From Metabolomics Analysis of Diabetic Retinopathy: Arginine-Creatine Metabolic Pathway May Be a New Treatment Strategy for Diabetic Retinopathy |
| Lingonberry | 📋 | | ⛔ | | 24690313 | Protective Effects of Bilberry and Lingonberry Extracts Against Blue Light-Emitting Diode Light-Induced Retinal Photoreceptor Cell Damage in Vitro |
| Lupeol | 📋 | | | | 34507119 | Intravitreal lupeol: A new potential therapeutic strategy for noninfectious uveitis |
| Magnolol | 📋 | | | | 36603340 | Magnolol regulates miR-200c-3p to inhibit epithelial-mesenchymal transition and retinoblastoma progression by modulating the ZEB1/E-cadherin axis in vitro and in vivo |
| Mango | 📋 | | ⛔ | | 28904737 | Anticataractogenesis and Antiretinopathy Effects of the Novel Protective Agent Containing the Combined Extract of Mango and Vietnamese Coriander in STZ-Diabetic Rats |
| MSM | 📋 | ✍ | ⛔ | | 24509160 | Metal chelator combined with permeability enhancer ameliorates oxidative stress-associated neurodegeneration in rat eyes with elevated intraocular pressure |
| Naringin | 📋 | ✍ | ⛔ | | 32172062 | Naringin Protects Against Bisphenol-A Induced Oculopathy as Implication of Cataract in Hypertensive Rat Model |
| Nattokinase | 📋 | ✍ | ⛔ | | 37403338 | Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy |
| Neferine | 📋 | | | | 35852698 | Effects of neferine on retinal tissue in experimental diabetic rat model |
| Oleuropein | 📋 | | | | 34613549 | Oleuropein Protects Human Retinal Pigment Epithelium Cells from IL-1β-Induced Inflammation by Blocking MAPK/NF-κB Signaling Pathways |
| Omega-6 Fatty Acids | 📋 | ✍ | ⛔ | | 33112826 | Association of n-6 PUFAs with the risk of diabetic retinopathy in diabetic patients |
| Paeonol | 📋 | | | | 36160440 | Paeonol attenuates retinopathy in streptozotocin-induced diabetes in rats by regulating the oxidative stress and polyol pathway |
| Pantethine | 📋 | ✍ | ⛔ | | 8674515 | Delay or inhibition of rat lens opacification using pantethine and WR-77913 |
| PEA | 📋 | ✍ | ⛔ | | 38269580 | Evaluation of the nutraceutical Palmitoylethanolamide in reducing intraocular pressure (IOP) in patients with glaucoma or ocular hypertension: a systematic review and meta-analysis |
| Piperine | 📋 | ✍ | ⛔ | | 34012879 | Protective effects of piperine on the retina of mice with streptozotocin-induced diabetes by suppressing HIF-1/VEGFA pathway and promoting PEDF expression |
| Piperlongumine | 📋 | | | | 36940616 | Piperlongumine inhibits proliferation and oncogenic MYCN expression in chemoresistant metastatic retinoblastoma cells directly and through extracellular vesicles |
| Pomegranate | 📋 | | ⛔ | | 29181308 | Protective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats |
| Potassium | 📋 | ✍ | ⛔ | | 37851631 | Association between dietary calcium, potassium, and magnesium consumption and glaucoma |
| PQQ | 📋 | ✍ | ⛔ | | 33318415 | Quercetin protects against diabetic retinopathy in rats by inducing heme oxygenase-1 expression |
| Procyanidins | 📋 | | ⛔ | | 34636125 | Procyanidin protects human retinal pigment epithelial cells from high glucose by inhibiting autophagy |
| Retinoic Acid | 📋 | | | | 35315776 | Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration |
| Roselle | 📋 | ✍ | ⛔ | | 28459020 | Disruption of Angiogenesis by Anthocyanin-Rich Extracts of Hibiscus sabdariffa |
| Safranal | 📋 | | | | 36465659 | Protective effects of safranal on diabetic retinopathy in human microvascular endothelial cells and related pathways analyzed with transcriptome sequencing |
| Salvianolic Acid | 📋 | | | | 37429233 | Protective benefits of salvianic acid A against retinal iron overload by inhibition of ferroptosis |
| Senolytics | 📋 | | | | 36091769 | Senolytics in the treatment of diabetic retinopathy |
| Spermidine | 📋 | | | | 37445726 | Spermidine Attenuates High Glucose-Induced Oxidative Damage in Retinal Pigment Epithelial Cells by Inhibiting Production of ROS and NF-κB/NLRP3 Inflammasome Pathway |
| Spikenard | 📋 | ✍ | ⛔ | | 29040017 | Aralia elata (Miq) Seem Extract Decreases O-GlcNAc Transferase Expression and Retinal Cell Death in Diabetic Mice |
| Tamarind | 📋 | | ⛔ | | 35330750 | A Plant-Derived Antioxidant Supplement Prevents the Loss of Retinal Ganglion Cells in the Retinas of NMDA-Injured Mice |
| Vitamin K1 | 📋 | ✍ | ⛔ | | 32721021 | The Effect of Dietary Vitamin K1 Supplementation on Trabecular Meshwork and Retina in a Chronic Ocular Hypertensive Rat Model |
| Acacetin | 📋 | | | | 36299901 | Acacetin protects against depression-associated dry eye disease by regulating ubiquitination of NLRP3 through gp78 signal |
| Acai Berry | 📋 | ✍ | ⛔ | | 37144218 | Neuroprotective effects of açaà ( Euterpe oleracea Mart.) against diabetic retinopathy |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 15947501 | Improvement of Visual Functions and Fundus Alterations in Early Age-Related Macular Degeneration Treated With a Combination of acetyl-L-carnitine, n-3 Fatty Acids, and Coenzyme Q10 |
| Aged Garlic | 📋 | ✍ | ⛔ | | 32141582 | S-allyl cysteine protects retinal pigment epithelium cells from hydroquinone-induced apoptosis through mitigating cellular response to oxidative stress |
| Allicin | 📋 | ✍ | ⛔ | | 26781848 | Allicin attenuates Hâ‚‚Oâ‚‚-induced cytotoxicity in retinal pigmented epithelial cells by regulating the levels of reactive oxygen species |
| Almond | 📋 | | ⛔ | | 33121423 | Terminalia catappa Fruit Extract Reverses Streptozotocin-Induced Diabetic Retinopathy in Rats |
| Aloe-Emodin | 📋 | | | | 27877088 | Aloe-emodin suppresses hypoxia-induced retinal angiogenesis via inhibition of HIF-1α/VEGF pathway |
| Aloin | 📋 | | | | 30380640 | Aloin Inhibits Müller Cells Swelling in a Rat Model of Thioacetamide-Induced Hepatic Retinopathy |
| Amaranth | 📋 | | ⛔ | | 34250604 | Aqueous extract prepared from steamed red amaranth (Amaranthus gangeticus L.) leaves protected human lens cells against high glucose induced glycative and oxidative stress |
| Amino Acids | 📋 | | | | 35390334 | An original amino acid formula favours in vitro corneal epithelial wound healing by promoting Fn1, ITGB1, and PGC-1α expression |
| Amygdalin | 📋 | ✍ | ⛔ | | 37422064 | Effects of amygdalin on ferroptosis and oxidative stress in diabetic retinopathy progression via the NRF2/ARE signaling pathway |
| Angelica | 📋 | ✍ | ⛔ | | 23662142 | An Aqueous Extract of Radix Astragali, Angelica sinensis, and Panax notoginseng Is Effective in Preventing Diabetic Retinopathy |
| Anthocyanidins | 📋 | | | | 35926946 | Blueberry anthocyanins extract attenuated diabetic retinopathy by inhibiting endoplasmic reticulum stress via the miR-182/OGG1 axis |
| Apricot Kernels | 📋 | ✍ | ⛔ | | 27886047 | Topical Application of Apricot Kernel Extract Improves Dry Eye Symptoms in a Unilateral Exorbital Lacrimal Gland Excision Mouse |
| Argan Oil | 📋 | ✍ | ⛔ | | 28849034 | Melanogenesis in uveal melanoma cells: Effect of argan oil |
| Artemisinin | 📋 | | | | 31741871 | Potential applications of artemisinins in ocular diseases |
| Aspirin | 📋 | | ⛔ | | 30964246 | Recurrent retinal vein thrombosis: prevention with Aspirin, Pycnogenol®, ticlopidine, or sulodexide |
| Bee Venom | 📋 | ✍ | ⛔ | | 35647524 | Low-dose melittin is safe for intravitreal administration and ameliorates inflammation in an experimental model of uveitis |
| Beta-Cryptoxanthin | 📋 | | | | 33628377 | Different Doses of β-Cryptoxanthin May Secure the Retina from Photooxidative Injury Resulted from Common LED Sources |
| Betulinic Acid | 📋 | | | | 34572088 | Betulinic Acid Protects from Ischemia-Reperfusion Injury in the Mouse Retina |
| Bilobalide | 📋 | | | | 35932369 | Protective Effects of the Bilobalide on Retinal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats |
| Bitter Melon | 📋 | ✍ | ⛔ | | 37862973 | Protective effects and mechanisms of Momordica charantia polysaccharide on early-stage diabetic retinopathy in type 1 diabetes |
| Bitter Orange | 📋 | ✍ | ⛔ | | 34647961 | Dietary Intervention With a Targeted Micronutrient Formulation Reduces the Visual Discomfort Associated With Vitreous Degeneration |
| Black Pepper | 📋 | ✍ | ⛔ | | 35406133 | Effect of a Fixed Combination of Curcumin, Artemisia, Bromelain, and Black Pepper Oral Administration on Optical Coherence Tomography Angiography Indices in Patients with Diabetic Macular Edema |
| Black Tea Polyphenols | 📋 | | | | 36544283 | Safety and Efficacy of Black Tea Extract in the Treatment of Acute Bacterial Conjunctivitis: A Rabbit Model |
| Boric Acid | 📋 | ✍ | ⛔ | | 34988929 | The Possible Protective Effect of Boric Acid in an Alkaline-Induced Corneal Neovascularization Rat Model |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 25913458 | Acetyl-11-keto-β-boswellic acid reduces retinal angiogenesis in a mouse model of oxygen-induced retinopathy |
| Butyrate | 📋 | | ⛔ | | 37420234 | Sodium butyrate ameliorates diabetic retinopathy in mice via the regulation of gut microbiota and related short-chain fatty acids |
| Camellia | 📋 | | ⛔ | | 28245300 | Anti-Inflammatory and Antioxidative Effects of Camellia japonica on Human Corneal Epithelial Cells and Experimental Dry Eye: In Vivo and In Vitro Study |
| Capsaicin | 📋 | ✍ | ⛔ | | 36088760 | Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress |
| Capsanthin | 📋 | | | | 35892258 | Capsanthin from Capsicum annum fruits exerts anti-glaucoma, antioxidant, anti-inflammatory activity, and corneal pro-inflammatory cytokine gene expression in a benzalkonium chloride-induced rat dry eye model |
| Carrot | 📋 | | ⛔ | | 33687088 | Vitamin A and Daucus carota root extract mitigate STZ-induced diabetic retinal degeneration in Wistar albino rats by modulating neurotransmission and downregulation of apoptotic pathways |
| Carvacrol | 📋 | ✍ | ⛔ | | 33913864 | Investigating the effects of carvacrol in rats using oxygen-induced retinopathy model |
| Catalpol | 📋 | | | | 34685615 | Catalpol Protects ARPE-19 Cells against Oxidative Stress via Activation of the Keap1/Nrf2/ARE Pathway |
| Chamomile | 📋 | ✍ | ⛔ | | 38142266 | EXPRESS: Antimicrobial effect of chamomile-containing over-the-counter ear and eye drops |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 34310352 | Swabs Containing Tea Tree Oil and Chamomile Oil Versus Baby Shampoo in Patients With Seborrheic Blepharitis: A Double-Blind Randomized Clinical Trial |
| Chebulinic Acid | 📋 | | | | 30189210 | Chebulagic acid and Chebulinic acid inhibit TGF-β1 induced fibrotic changes in the chorio-retinal endothelial cells by inhibiting ERK phosphorylation |
| Chia Seeds | 📋 | | ⛔ | | 36760936 | Mitigation of photoreceptors abnormalities after low-level laser therapy and chia seeds supplementation in experimental diabetic retinopathy |
| Chlorella | 📋 | ✍ | ⛔ | | 14703308 | Antioxidant and anti-cataract effects of Chlorella on rats with streptozotocin-induced diabetes |
| Cinnamaldehyde | 📋 | | | | 27386147 | Cinnamaldehyde Attenuates Cataractogenesis via Restoration of Hypertension and Oxidative Stress in Fructose-Fed Hypertensive rats |
| Cinnamon | 📋 | ✍ | ⛔ | | 33013014 | Cinnamon Attenuated Long-Term IGT-Induced Retinal Abnormalities via Regulation of Glucose Homeostasis in Neonatal Streptozotocin Induced Rat Model |
| Clove Essential Oil | 📋 | | ⛔ | | 29634373 | Potential Alternative Treatment of Ocular Bacterial Infections by Oil Derived from Syzygium aromaticum Flower (Clove) |
| Coconut | 📋 | | ⛔ | | 33575128 | Effects of coconut water on blood sugar and retina of rats with diabetes |
| Cordycepin | 📋 | | | | 36178076 | Cordycepin inhibited the retinoblastoma cell proliferation, migration and invasion as well as lung metastasis via modulating c-Myc/cyclin D1 pathway |
| Corn | 📋 | | ⛔ | | 38140323 | Purple Corn Extract Improves Dry Eye Symptoms in Models Induced by Desiccating Stress and Extraorbital Lacrimal Gland Excision |
| Creatine | 📋 | ✍ | ⛔ | | 35399942 | A Hypothesis From Metabolomics Analysis of Diabetic Retinopathy: Arginine-Creatine Metabolic Pathway May Be a New Treatment Strategy for Diabetic Retinopathy |
| Daidzein | 📋 | ✍ | ⛔ | | 33217441 | Daidzein ameliorates diabetic retinopathy in experimental animals |
| DHEA | 📋 | ✍ | ⛔ | | 36811237 | Low serum dehydroepiandrosterone levels are associated with diabetic retinopathy in patients with type 2 diabetes mellitus |
| Dihydroartemisinin | 📋 | | | | 34619345 | Dihydroartemisinin ameliorates retinal vascular dysfunction in diabetes mellitus via the FASN/Kmal-mTOR/SREBP1 feedback loop |
| Dioscin | 📋 | | | | 35153764 | Dioscin Reduces Vascular Damage in the Retina of db/db Mice by Inhibiting the VEGFA Signaling Pathway |
| Echinacea | 📋 | ✍ | ⛔ | | 17238809 | Oral Echinacea Purpurea Extract in Low-Grade, Steroid-Dependent, Autoimmune Idiopathic Uveitis: A Pilot Study |
| Elderberry | 📋 | ✍ | ⛔ | | 34960000 | A Pilot, Phase II, Observational, Case-Control, 1-Month Study on Asthenopia in Video Terminal Operators without Dry Eye: Contrast Sensitivity and Quality of Life before and after the Oral Consumption of a Fixed Combination of Zinc, L-Carnitine, Extract of Elderberry, Currant and Extract of Eleutherococcus |
| Eleuthero | 📋 | ✍ | ⛔ | | 34960000 | A Pilot, Phase II, Observational, Case-Control, 1-Month Study on Asthenopia in Video Terminal Operators without Dry Eye: Contrast Sensitivity and Quality of Life before and after the Oral Consumption of a Fixed Combination of Zinc, L-Carnitine, Extract of Elderberry, Currant and Extract of Eleutherococcus |
| Eucalyptol | 📋 | | | | 33076507 | Eucalyptol Inhibits Amyloid-β-Induced Barrier Dysfunction in Glucose-Exposed Retinal Pigment Epithelial Cells and Diabetic Eyes |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 18313350 | Oral omega-6 essential fatty acid treatment in contact lens associated dry eye |
| Fiber | 📋 | ✍ | ⛔ | | 37402809 | A diet rich in fermentable fiber promotes robust changes in the intestinal microbiota, mitigates intestinal permeability, and attenuates autoimmune uveitis |
| Frankincense | 📋 | ✍ | ⛔ | | 35956066 | Anatomical and Functional Effects of Oral Administration of Curcuma Longa and Boswellia Serrata Combination in Patients with Treatment-Naïve Diabetic Macular Edema |
| Fruits | 📋 | | | | 36973404 | Fruit and vegetable intake and the risk of cataract: insights from the UK Biobank study |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 34882608 | Effect of a Novel Omega-3 and Omega-6 Fatty Acid Supplement on Dry Eye Disease: A 3-month Randomized Controlled Trial |
| Gingerol | 📋 | ✍ | | | 27293376 | Zingiber officinale attenuates retinal microvascular changes in diabetic rats via anti-inflammatory and antiangiogenic mechanisms |
| Glycine | 📋 | ✍ | ⛔ | | 35777472 | Preclinical study of a new matrix to help the ocular surface in dry eye disease |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 36422579 | Glycyrrhizin Interacts with TLR4 and TLR9 to Resolve P. aeruginosa Keratitis |
| Haritaki | 📋 | ✍ | ⛔ | | 35168075 | Triphala churna ameliorates retinopathy in diabetic rats |
| Hawthorn | 📋 | ✍ | ⛔ | | 33491221 | Hawthorn polyphenols reduce high glucose-induced inflammation and apoptosis in ARPE-19 cells by regulating miR-34a/SIRT1 to reduce acetylation |
| Hazelnut | 📋 | | ⛔ | | 16049376 | Doxorubicin-induced cataract formation in rats and the inhibitory effects of hazelnut, a natural antioxidant: a histopathological study |
| Holy Basil | 📋 | ✍ | ⛔ | | 16020293 | Ocimum Sanctum Modulates Selenite-Induced Cataractogenic Changes and Prevents Rat Lens Opacification |
| Honeysuckle | 📋 | | ⛔ | | 38612968 | Extract from Aronia melanocarpa, Lonicera caerulea, and Vaccinium myrtillus Improves near Visual Acuity in People with Presbyopia |
| Honokiol | 📋 | | | | 36933490 | Honokiol reduces fungal burden and ameliorate inflammation lesions of Aspergillus fumigatus keratitis via Dectin-2 down-regulation |
| Hydroxytyrosol | 📋 | | | | 29278909 | Neuroprotective Effect of Hydroxytyrosol in Experimental Diabetic Retinopathy: Relationship with Cardiovascular Biomarkers |
| Icariin | 📋 | ✍ | | | 35334248 | Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization |
| Isoliquiritigenin | 📋 | | | | 32699958 | Isoliquiritigenin downregulates miR-195 and attenuates oxidative stress and inflammation in STZ-induced retinal injury |
| Isorhamnetin | 📋 | | | | 38331017 | Isorhamnetin suppresses the epithelial-mesenchymal transition of the retinal pigment epithelium both in vivo and in vitro through Nrf2-dependent AKT/GSK-3β pathway |
| L-Leucine | 📋 | ✍ | ⛔ | | 35321336 | The Association Between Leucine and Diabetic Retinopathy in Different Genders: A Cross-Sectional Study in Chinese Patients With Type 2 Diabetes |
| L-Lysine | 📋 | ✍ | ⛔ | | 34647961 | Dietary Intervention With a Targeted Micronutrient Formulation Reduces the Visual Discomfort Associated With Vitreous Degeneration |
| Lemon Balm | 📋 | ✍ | ⛔ | | 26941573 | Melissa Officinalis L. Extracts Protect Human Retinal Pigment Epithelial Cells against Oxidative Stress-Induced Apoptosis |
| Lettuce | 📋 | | ⛔ | | 33705802 | Lactucaxanthin protects retinal pigment epithelium from hyperglycemia-regulated hypoxia/ER stress/VEGF pathway mediated angiogenesis in ARPE-19 cell and rat model |
| Lime | 📋 | | ⛔ | | 32539198 | Citrus Hystrix Leaf Extract Attenuated Diabetic-Cataract in STZ-rats |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 33982092 | Causal Effects of N-6 Polyunsaturated Fatty Acids on Age-related Macular Degeneration: A Mendelian Randomization Study |
| Lotus | 📋 | | ⛔ | | 34949755 | Lotus Seedpod Proanthocyanidins Protect Against Light-Induced Retinal Damage via Antioxidative Stress, Anti-Apoptosis, and Neuroprotective Effects |
| Lychee | 📋 | | ⛔ | | 37703661 | Lychee seed polyphenol ameliorates DR via inhibiting inflammasome/apoptosis and angiogenesis in hRECs and db/db mice |
| Malva Sylvestris | 📋 | | ⛔ | | 37924786 | Potential benefits of Malva sylvestris in dry-eye disease pathology in vitro based on antioxidant, wound-healing and anti-inflammatory properties |
| Malvidin | 📋 | | | | 29682153 | Antioxidant and Anti-Inflammatory Effects of Blueberry Anthocyanins on High Glucose-Induced Human Retinal Capillary Endothelial Cells |
| Mangiferin | 📋 | | ⛔ | | 33899114 | Mangiferin inhibits cell migration and angiogenesis via PI3K/AKT/mTOR signaling in high glucose‑ and hypoxia‑induced RRCECs |
| Matcha Tea | 📋 | | | | 35987428 | Effect of green tea and tea catechin on the visual motion processing for optokinetic responses in mice |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 19556244 | Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 31226981 | Effect of Moringa oleifera stem extract on hydrogen peroxide-induced opacity of cultured mouse lens |
| Mulberry | 📋 | | ⛔ | | 35417907 | Mulberry Leaf Extract Alleviates Staphylococcus aureus-Induced Conjunctivitis in Rabbits via Downregulation of NLRP3 Inflammasome and Upregulation of the Nrf2 System and Suppression of Pro-Inflammatory Cytokines |
| Myricetin | 📋 | | ⛔ | | 25450667 | Myricetin inhibits advanced glycation end product (AGE)-induced migration of retinal pericytes through phosphorylation of ERK1/2, FAK-1, and paxillin in vitro and in vivo |
| Nimbolide | 📋 | | | | 34354407 | Nimbolide ameliorates the streptozotocin-induced diabetic retinopathy in rats through the inhibition of TLR4/NF-κB signaling pathway |
| Oleanolic Acid | 📋 | | | | 36714956 | Network pharmacology study of the mechanism underlying the therapeutic effect of Zhujing pill and its main component oleanolic acid against diabetic retinopathy |
| Olive Oil | 📋 | ✍ | ⛔ | | 19433719 | Fat consumption and its association with age-related macular degeneration |
| Orange | 📋 | | ⛔ | | 29982448 | Dietary flavonoids and the prevalence and 15-y incidence of age-related macular degeneration |
| Papain | 📋 | ✍ | ⛔ | | 36431188 | A New Pharmacological Vitreolysis through the Supplement of Mixed Fruit Enzymes for Patients with Ocular Floaters or Vitreous Hemorrhage-Induced Floaters |
| Phloretin | 📋 | | | | 35771396 | Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells |
| Phosphatidylcholine | 📋 | ✍ | ⛔ | | 21060672 | Management of Chronic Anterior Uveitis Relapses: Efficacy of Oral Phospholipidic Curcumin Treatment. Long-term Follow-Up |
| Polydatin | 📋 | ✍ | | | 31731792 | Polydatin Inhibits NLRP3 Inflammasome in Dry Eye Disease by Attenuating Oxidative Stress and Inhibiting the NF-κB Pathway |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 35894450 | The protective effect of pomegranate peel aqueous extract on selenite-induced cataract in rats |
| Postbiotics | 📋 | | | | 38500583 | Postbiotics: emerging therapeutic approach in diabetic retinopathy |
| Prebiotics | 📋 | ✍ | ⛔ | | 36013128 | The Impact of Probiotics and Prebiotics on Dry Eye Disease Signs and Symptoms |
| Probiotics | 📋 | ✍ | ⛔ | | 36013128 | The Impact of Probiotics and Prebiotics on Dry Eye Disease Signs and Symptoms |
| Prunella Vulgaris | 📋 | ✍ | ⛔ | | 36242032 | Fallopia Japonica and Prunella vulgaris inhibit myopia progression by suppressing AKT and NFκB mediated inflammatory reactions |
| Rehmannia | 📋 | ✍ | ⛔ | | 34234414 | Exploration of the Effect and Mechanism of Fructus Lycii, Rehmanniae Radix Praeparata, and Paeonia lactiflora in the Treatment of AMD Based on Network Pharmacology and in vitro Experimental Verification |
| Rosmarinic Acid | 📋 | ✍ | | | 37407754 | Low-dose rosmarinic acid and thymoquinone accelerate wound healing in retinal pigment epithelial cells |
| Royal Jelly | 📋 | ✍ | ⛔ | | 34444696 | Acetylcholine and Royal Jelly Fatty Acid Combinations as Potential Dry Eye Treatment Components in Mice |
| Sesamin | 📋 | ✍ | | | 35020533 | Sesamin suppresses high glucose-induced microglial inflammation in the retina in vitro and in vivo |
| Silibinin | 📋 | ✍ | | | 37906058 | Silibinin Prevents TGFβ-Induced EMT of RPE in Proliferative Vitreoretinopathy by Inhibiting Stat3 and Smad3 Phosphorylation |
| Silymarin | 📋 | ✍ | ⛔ | | 36151457 | Silymarin reduces retinal microvascular damage in streptozotocin-induced diabetic rats |
| Sirtuin Activators | 📋 | | | | 35409409 | Biochemical Functions and Clinical Characterizations of the Sirtuins in Diabetes-Induced Retinal Pathologies |
| Skullcap | 📋 | ✍ | ⛔ | | 34103952 | Scutellaria barbata D. Don Polysaccharides Inhibit High Glucose-Induced Proliferation and Angiogenesis of Retinal Vascular Endothelial Cells |
| Syringic Acid | 📋 | | | | 33704647 | Protective effect of syringic acid via restoring cells biomechanics and organelle structure in human lens epithelial cells |
| Tangeretin | 📋 | | | | 33354576 | Tangeretin Inhibition of High-Glucose-Induced IL-1 β, IL-6, TGF- β 1, and VEGF Expression in Human RPE Cells |
| Tannic Acid | 📋 | ✍ | ⛔ | | 33078305 | Grape seed proanthocyanidins protect retinal ganglion cells by inhibiting oxidative stress and mitochondrial alteration |
| Tea | 📋 | | | | 36185328 | Habitual Tea Consumption and Risk of Cataracts: A Longitudinal Study |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 32774685 | Tribulus terrestris Ameliorates Oxidative Stress-Induced ARPE-19 Cell Injury through the PI3K/Akt-Nrf2 Signaling Pathway |
| Urolithins | 📋 | | | | 35321989 | Urolithin A ameliorates diabetic retinopathy via activation of the Nrf2/HO-1 pathway |
| Vegetables | 📋 | | | | 36973404 | Fruit and vegetable intake and the risk of cataract: insights from the UK Biobank study |
| Walnut | 📋 | | ⛔ | | 29299206 | Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat |
| Whey Protein | 📋 | ✍ | ⛔ | | 35215448 | The Panax ginseng Berry Extract and Soluble Whey Protein Hydrolysate Mixture Ameliorates Sarcopenia-Related Muscular Deterioration in Aged Mice |
| Wine | 📋 | | ⛔ | | 33260857 | Red Wine Extract Inhibits VEGF Secretion and Its Signaling Pathway in Retinal ARPE-19 Cells to Potentially Disrupt AMD |
| Withaferin A | 📋 | | | | 36231074 | Withaferin a Attenuates Retinal Ischemia-Reperfusion Injury via Akt-Dependent Inhibition of Oxidative Stress |
| Wogonin | 📋 | ✍ | ⛔ | | 28260013 | Wogonin Protects Human Retinal Pigment Epithelium Cells From LPS-induced Barrier Dysfunction and Inflammatory Responses by Regulating the TLR4/NF-κB Signaling Pathway |
| Yerba Mate | 📋 | ✍ | ⛔ | | 35279946 | Ilex Paraguariensis Extracts Prevent Oxidative Damage in a Mouse Model of Age-Related Macular Degeneration |
